IPAK · In Development
Pre-Registered Biomedical and Clinical Science
A public-good registry and verification engine for trustworthy medical evidence.
Launching 2026 · A program of the Institute for Pure and Applied Knowledge
Pre-registration was meant to stop the practices that manufacture false findings — outcome switching, moving the goalposts after the data arrive, silent changes to who counts and what is measured. In practice, registered plans are routinely abandoned without disclosure. In the first audit of its kind, 93% of pre-registered studies deviated from plan, and roughly 89% of those did not disclose every change (Claesen et al., 2021). In clinical trials, the same undisclosed outcome-switching appears even in the highest-impact medical journals.
No existing platform checks whether the published paper matches the plan, and none is built for the clinical and biomedical research where the stakes reach the patient. We are building the one that is — and giving it to the research community as a public good.
What it will do
A registration instrument built for biomedicine
Mandatory power and effect-size justification, a locked primary/secondary/exploratory outcome hierarchy, a pre-specified multiplicity-control plan, interim and stopping rules, and a safety-monitoring plan — with a de-identification standard so it can hold clinical work safely.
A verification and concordance engine
At publication, the platform compares the registered plan against the reported study and surfaces every divergence, separating disclosed deviations from silent ones. Each completed study earns a public, immutable concordance record.
Integrity governance
Time-stamped, immutable, and web-archived, with oversight through the IPAK IRB. Mandatory eventual disclosure closes the file-drawer loophole: a prediction, once registered, cannot be quietly erased.
Built for the domains where reform is overdue
- Environmental Health & Toxicology
- Vaccine Safety & Biologics Surveillance
- Autism & Pediatric Neurodevelopment
- Mental Health & Neuropsychiatry
- Chronic & Post-Viral Illness
- Iatrogenic Disease & Patient Safety
- Metabolic, Nutritional & Pancreatic Health
- Alternative & Integrative Therapeutics
A public good, funded by gifts
The registry will be free to every researcher who uses it. It is funded philanthropically, and any service revenue is returned to the program rather than taken as profit. To support the work or register early interest, reach IPAK below.
Institute for Pure and Applied Knowledge · IPAK-EDU LLC
Claesen, A., Gomes, S., Tuerlinckx, F., & Vanpaemel, W. (2021). Comparing dream to reality: an assessment of adherence of the first generation of preregistered studies. Royal Society Open Science, 8(10), 211037.